My current research interests include
- Comparative genomics within and between clades.
- Evolutionary rate estimation.
- Visualization of genomic data.
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I belong to the Comparative genomics group
headed by Chris Ponting.
My current research interests include
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| 1992/1996 | Student of Biotechnology at the Technical University of Braunschweig, Germany |
| 1996/1997 | Trainee in Haruki Nakamura's group at the Biomolecular Engineering Research Institute (BERI), Osaka |
| 1998/2002 | PhD at the EBI in Hinxton, Cambridge |
| 2002/2004 | PostDoc in Liisa Holm's Bioinformatics group at the University of Helsinki, Finland |
| 2004/present | Investigator scientist in the Comparative genomics group at the MRC Functional Genetics Unit, Oxford, Uk |
| RADAR | C | A program to find repeats in protein sequences. |
| ADDA | C++ | An algorithm to find domains in protein sequences. |
| alignlib | C++ | A C++ library with python bindings for classic sequence alignment. |
| OPTIC | OPTIC: Orthologous and paralogous transcripts in clades. |
| Platypus genome analysis | Assisting Chris Ponting with gene prediction and orthology analysis. |
| Monodelphis genome analysis | Assisting Chris Ponting and Leo Goodstadt with gene prediction and analysis. |
| Comparative genomics of fruit flies | Gene prediction, orthology and rate analysis in 12 fruit flies. See also the AAA Wiki |
| ADDA | An algorithm to find domains in protein sequences (and a database). |
| PairsDB | A database of all-vs-all pre-computed BLAST and PSIBLAST alignments. |
| Global Trace Graph | A method for fold prediction. |
| RADAR | A program to find repeats in protein sequences. |
| RSDB | A database of non-redundant protein sequences at different levels of similarity. |
Heger, A., Mallick, S., Wilton, C. et al.. (2007). The global trace graph, a novel paradigm for searching protein sequence databases.. Bioinformatics 23, 2361-2367.
Goodstadt, L., Heger, A., Webber, C. et al.. (2007). An analysis of the gene complement of a marsupial, monodelphis domestica: evolution of lineage-specific genes and giant chromosomes.. Genome Res 17, 969-981.
Heger, A. and Ponting, CP.. (2007). Variable strength of translational selection among 12 drosophila species.. Genetics 177, 1337-1348.
Heger, A. and Ponting, CP.. (2007). Evolutionary rate analyses of orthologs and paralogs from 12 drosophila genomes.. Genome Res 17, 1837-1849.
Heger, A. and Ponting, CP.. (2007). Optic: orthologous and paralogous transcripts in clades.. Nucleic Acids Res , .
Clark, AG., Eisen, MB., Smith, DR. et al.. (2007). Evolution of genes and genomes on the drosophila phylogeny.. Nature 450, 203-218.
Heger, A., Korpelainen, E., Hupponen, T. et al.. (2007). Pairsdb atlas of protein sequence space.. Nucleic Acids Res , .
Heger, A., Wilton, CA., Sivakumar, A. et al.. (2005). Adda: a domain database with global coverage of the protein universe. Nucleic Acids Res 33, D188-91.
Lindblad-Toh, K., Wade, CM., Mikkelsen, TS. et al.. (2005). Genome sequence, comparative analysis and haplotype structure of the domestic dog. Nature 438, 803-819.
Heger, A., Lappe, M. and Holm, L.. (2004). Accurate detection of very sparse sequence motifs. J Comput Biol 11, 843-857.
Heger, A. and Holm, L.. (2003). Exhaustive enumeration of protein domain families. J Mol Biol 328, 749-767.
Heger, A. and Holm, L.. (2003). More for less in structural genomics. J Struct Funct Genomics 4, 57-66.
Heger, A. and Holm, L.. (2003). Sensitive pattern discovery with 'fuzzy' alignments of distantly related proteins. Bioinformatics 19 Suppl 1, i130-7.
Heger, A. and Holm, L.. (2003). Exhaustive enumeration of protein domain families. J Mol Biol 328, 749-767.
Heger, A. and Holm, L.. (2001). Picasso: generating a covering set of protein family profiles. Bioinformatics 17, 272-279.
Dietmann, S., Park, J., Notredame, C. et al.. (2001). A fully automatic evolutionary classification of protein folds: dali domain dictionary version 3. Nucleic Acids Res 29, 55-57.
Park, J., Holm, L., Heger, A. et al.. (2000). Rsdb: representative protein sequence databases have high information content. Bioinformatics 16, 458-464.
Heger, A. and Holm, L.. (2000). Rapid automatic detection and alignment of repeats in protein sequences. Proteins 41, 224-237.
Heger, A. and Holm, L.. (2000). Towards a covering set of protein family profiles. Prog Biophys Mol Biol 73, 321-337.
Park, J., Dietmann, S., Heger, A. et al.. (2000). Estimating the significance of sequence order in protein secondary structure and prediction. Bioinformatics 16, 978-987.
Heger, A., Higo, J. and Nakamura, H.. (1997). Model building study of complex structures using nmrchemical shift change information.. Proc. Japan Acad. 73B, 109-113.